Emulgel is the most emerging and successful formulation to deliver hydrophobic drugs. It imbibes the properties of both gel and emulsion which results in enhancing the solubility of the hydrophobic drug to make the drug more bioavailable and enhances the patient compliance as topical drug delivery dosage form. Aceclofenac is NSAID, derivative of diclofenac, used as analgesic and anti-inflammatory agent belongs to BCS class – II drug (low solubility and high permeability) is taken as a drug of choice to formulate as Emulgel. It facilitates in by-passing the drug from GI exposure, hence it reduces the gastric complications of the drug. Less dose is sufficient to prepare as topical dosage form. Here, emulgels were prepared as 1.5% w/w formulation by using carbopol 934 and HPMC K4M separately as gelling agents. Mentha oil as penetration enhancer. Emulgels were prepared and evaluated for rheological properties, pH determination, drug release profiles and skin irritation tests. The present study reveals that the formulation using carbopol 934 shown better release profile than HPMC K4M which depicts, carbopol 934 is the better choice of polymer to prepare aceclofenac emulgel.
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